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目的 :探讨经皮冠状动脉介入(PCI)术前24h内给予负荷剂量(80mg)阿托伐他汀对不稳定心绞痛患者PCI术后心肌损伤的影响。方法 :将200例需经PCI治疗不稳定心绞痛患者根据随机数字表法分为观察组和对照组,观察组术前应用80mg阿托伐他汀,对照组术前给予20mg阿托伐他汀。比较两组肌钙蛋白、B型脑钠肽前体(NT-pro BNP)、高敏C-反应蛋白(Hs-CRP)、肌酸激酶同工酶(CK-MB)水平变化情况以及患者术后1月内随访不良心血管事件发生率。结果 :(1)两组患者手术后心肌肌钙蛋白、NT-pro BNP、Hs-CRP、CK-MB水平明显高于手术前,差异有统计学意义,观察组上述指标明显低于对照组,差异有统计学意义;(2)观察组心源性再住院、心绞痛复发发生率及心血管事件总发生率均明显低于对照组,差异均有统计学意义。结论 :PCI术前应用负荷剂量阿托品能够有效的降低PCI术后心肌损伤,并能够降低患者心血管事件发生率。
Objective: To investigate the effect of atorvastatin at a loading dose (80 mg) within 24 hours before percutaneous coronary intervention (PCI) on myocardial injury in patients with unstable angina after PCI. Methods: 200 cases of patients with unstable angina pectoris undergoing PCI were divided into observation group and control group according to random number table method. Atorvastatin 80 mg in the observation group and 20 mg atorvastatin in the control group before operation. The levels of troponin B, NT-pro BNP, Hs-CRP and CK-MB were compared between the two groups The incidence of adverse cardiovascular events during January was followed up. Results: (1) The levels of cardiac troponin, NT-pro BNP, Hs-CRP and CK-MB in the two groups after operation were significantly higher than those before operation. The above indexes in the observation group were significantly lower than those in the control group The difference was statistically significant; (2) The observation group cardiogenic rehospitalization, the incidence of angina relapse and the overall incidence of cardiovascular events were significantly lower than the control group, the differences were statistically significant. Conclusion: Atropine loading dose before PCI can effectively reduce myocardial injury after PCI, and can reduce the incidence of cardiovascular events in patients.