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探讨人绒毛膜促性腺激素(hCG)是否具有垂体促甲状腺激素(TSH)样作用。方法:应用放射免疫方法(RIA)对65例旱孕妇女hCG与甲状腺激素水平进行测定。结果:早孕妇女Ⅰ组(停经35—50天)3,3’,5’-三碘甲状腺原氨酸(rT_3)水平升高,与正常对照组差异显著(P<0.01);早孕妇女Ⅱ组(停经51—80天)甲状腺素(T_4)、游离甲状腺素(FT_4)、rT_3水平均升高,与正常对照组差异显著(P<0.01);而两组早孕妇女的三碘甲状腺原氨酸(T_3)、游离三碘甲状腺原氨酸(FT_3)水平与正常对照组无明显差异(P>0.05)。结论:hCG具有TSH样作用,早孕妇女甲状腺激素水平升高为hCG促使甲状腺功能增强所致。
To investigate whether human chorionic gonadotropin (hCG) has pituitary thyroid stimulating hormone (TSH) -like effect. Methods: The hCG and thyroid hormone levels in 65 women with dry pregnancy were determined by radioimmunoassay (RIA). Results: The level of 3,3 ’, 5’-triiodothyronine (rT_3) increased in group Ⅰ (35-50 days after menopause), significantly different from the normal control group (P0.01) (51-80 days after menopause), thyroxine (T_4), free thyroxine (FT_4) and rT_3 increased, which were significantly different from those in normal control group (P <0.01). The levels of triiodothyronine (T_3) and free triiodothyronine (FT_3) levels were not significantly different from the normal control group (P> 0.05). Conclusion: hCG has TSH-like effect. The increase of thyroid hormone in early pregnant women is caused by the enhancement of thyroid function by hCG.