论文部分内容阅读
目的 了解育龄妇女在月经周期中血清抑制素 (INH)含量的变化规律及其与卵泡刺激素 (FSH)、黄体生成素 (LH)、雌二醇 (E2 )及孕酮 (P)的相关性。方法 建立一种改良的INH放射免疫测定法 (RIA) ,对育龄妇女正常月经周期中及绝经后妇女血清INH含量的变化进行监测 ;同时测定血清FSH、LH、E2 及P含量 ,分析INH与FSH、LH、E2 及P之间的相关性。结果 血清INH含量在月经周期中具有规律性变化 ,从滤泡期开始逐渐升高 ,在黄体中期达峰值 ;在滤泡期和黄体期 ,血清INH和FSH含量呈显著负相关 ,rs=- 0 483 ,P <0 0 1;围排卵期 ,两者间无明显相关性 ,P >0 0 5。滤泡期 ,血清E2 含量与INH含量呈显著正相关 ,r =0 39,P <0 0 5 ;围排卵期 ,血清INH含量与血清E2 含量相关性更为明显 ,r =0 47,P <0 0 5 ;血清INH含量与血清LH含量间无相关性 ,P >0 0 5。黄体中期 ,血清INH含量与血清P含量间呈现明显正相关 ,r =0 6 8,P <0 0 1;但与血清E2 含量间不存在相关性 ,P >0 0 5。结论 INH在月经生理中具有重要的调节作用 ,尤其对垂体合成分泌FSH的抑制作用 ,确切机制尚有待于进一步研究探讨。
Objective To investigate the changes of serum inhibin (INH) in women of childbearing age and their correlation with follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2) and progesterone . Methods A modified INH radioimmunoassay (RIA) was established to detect the changes of serum INH levels in women of childbearing age during the normal menstrual cycle and in postmenopausal women. Meanwhile, the levels of serum FSH, LH, E2 and P were measured, and the correlation between INH and FSH , LH, E2 and P between the correlation. Results The content of INH in serum had a regular change in the menstrual cycle and gradually increased from the follicular stage to the peak in the middle of the corpus luteum. There was a significant negative correlation between the content of INH and FSH in the follicular phase and the luteal phase, rs = - 0 483, P <0 01; ovulation period, no significant correlation between the two, P> 0 0 5. Follicular phase, serum E2 content and INH content was positively correlated (r = 0 39, P <0 05; ovulation period, serum INH content and serum E2 content was more significant, r = 0 47, P < There was no correlation between serum INH content and serum LH content (P> 0.05). There was a significant positive correlation between serum INH content and serum P content in the mid luteal phase, r = 0 6 8, P 0 01; however, there was no correlation with serum E2, P 0 05. Conclusion INH plays an important regulatory role in menstrual physiology. In particular, the exact mechanism of inhibition of pituitary FSH secretion remains to be further explored.