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本工作用磷钼蓝比色法研究发现,在缺氧的中性水溶液中,硝基杂环化合物N-6、N-8对5’鸟苷酸(5’-GMP)的γ射线辐解过程中无机磷的释放均有敏化效应,其中以N-8较佳,但它们的敏化效果都与敏化剂的浓度和辐照剂量有关,其化学增强比C.E.R’=G(P_1)有敏化剂/G(P_1)无敏化剂,对于同一浓度的敏化剂,随剂量的增大而减小;而在同一剂量条件下,则随敏化剂浓度的增大而增大。敏化机制则是由于电子从5’-鸟苷酸的C’_5自由基向硝基杂环化合物(一种亲电子敏化剂S)转移形成阳碳离子继而水解的结果,从而增加了γ射线辐射诱发无机磷释放的产额G(R_1)。
The work using phosphomolybdate blue colorimetric method found that in a neutral aqueous solution of hypoxia, the nitro-heterocyclic compounds N-6, N-8 of 5 ’guanosinic acid (5’-GMP) γ-ray radiolysis In the process of inorganic phosphorus release have sensitization effect, which N-8 is better, but their sensitization effect with the concentration of sensitizer and irradiation dose, the chemical enhancement ratio of CER ’= G (P_1 ) Sensitizer / G (P 1) sensitizer, with the same concentration of sensitizer decreases with increasing dose; while the same dose conditions, with the concentration of sensitizer increased Big. Sensitization mechanism is due to the electron from the 5’-guanylic acid C’_5 free radicals to nitro-heterocyclic compounds (an electrophilic sensitizer S) transfer to form a positive carbon ions and hydrolysis results, thereby increasing the γ Yield of inorganic phosphorus release G (R_1) induced by radiation.