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目的:对西地那非治疗新生儿持续性肺动脉高压的效果进行分析和研究。方法:回顾我院在2013年6月——2017年6月期间所收治的共21例持续性肺动脉高压新生儿作为主要的研究对象,将患儿分为对照组和治疗组。对照组10例和治疗组11例,对二组患儿均给予维持内环境和抗感染、猪肺磷脂、呼吸支持等对症治疗,在此基础上治疗组患儿使用枸橼酸西地那非片治疗,对二组患儿的临床治疗效果进行比较。同时对患儿所出现的不良反应情况进行比较。结果:对照组的治疗整体有效率为(70%),治疗组的治疗有效率为(81.8%),二组相比较差异十分明显,具有统计学意义(P<0.05)。同时在不良反应方面二组患儿均未出现明显不良反应(P>0.05)。结论:西地那非治疗新生儿持续性肺动脉高压能够有效的提升治疗效果,对于患儿来说也不容易发生不良反应,效果显著值得在基层临床上进行推广。西地那非;新生儿;持续性肺动脉高压;效果
Objective: To analyze and study the effect of sildenafil in the treatment of persistent pulmonary hypertension in newborns. Methods: A total of 21 neonates with persistent pulmonary hypertension who were admitted to our hospital from June 2013 to June 2017 were selected as the main study subjects. The children were divided into control group and treatment group. 10 cases in the control group and 11 cases in the treatment group were given symptomatic treatment to maintain the internal environment and anti-infective, pulmonary phlebitis, respiratory support and other two groups of children, on the basis of the treatment group children with sildenafil citrate Tablets treatment, the clinical efficacy of two groups of children were compared. At the same time the adverse reactions occurred in children were compared. Results: The overall effective rate was 70% in the control group and 81.8% in the treatment group. There was significant difference between the two groups (P <0.05). At the same time, there was no obvious adverse reactions in both groups in terms of adverse reactions (P> 0.05). Conclusion: Sildenafil treatment of persistent pulmonary hypertension in neonates can effectively improve the therapeutic effect, and is not prone to adverse reactions in children, the effect is worth to promote in the primary clinical. Sildenafil; Neonate; Persistent Pulmonary Hypertension; Effect