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目的评价泰勒宁胶囊用于中晚期癌痛的镇痛效果并与曲马多胶囊比较。方法58例中晚期癌痛患者随机分为泰勒宁组(T组n=30)和曲马多组(Q组n=28);用双盲法观察两组病人的镇痛效果、不良反应。结果两组病人均取得良好的镇痛疗效,用药7d后中度以上疼痛缓解率和完全缓解率,T组分别为100%和83,3%;Q组分别为964%和714%,两组相比较差异无显著性(P>005);用药期间有部分患者出现头晕、嗜睡和恶心、呕吐,皮肤瘙痒,皮疹,未见明显的呼吸抑制及精神依赖性。结论泰勒宁胶囊为临床药物治疗癌痛提供了一个新的选择。
Objective To evaluate the analgesic efficacy of Tyrannin capsules for advanced cancer pain and to compare with tramadol capsules. Methods Fifty-eight patients with moderate and advanced stage cancer pain were randomly divided into two groups: Tylenol group (n = 30 in T group) and tramadol group (n = 28 in Q group). The analgesic effects and adverse reactions of the two groups were observed by double-blind method. Results The two groups of patients achieved good analgesic efficacy. Medication pain relief rate and complete remission rate after 7 days of treatment were 100% and 83.3% in group T, 964% and 714% in group T, respectively There was no significant difference between the two groups (P> 0.05). Some patients experienced dizziness, drowsiness, nausea, vomiting, pruritus and skin rashes during the course of medication. No obvious respiratory depression and psychic dependence were observed. Conclusion Tylenol capsule provides a new choice for clinical drug treatment of cancer pain.