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本文观察了超氧化物歧化酶(SOD)对大鼠乙酸性结肠炎的粘膜保护作用。与生理盐水组对照,预防性静脉给予1万USOD能显著降低粘膜损伤指数以及肠粘连和狭窄的发生率。但是,腹腔注射与灌肠相同剂量的SOD与各自生理盐水对照组比较,并无显著差别。SOD的粘膜保护作用呈剂量效应。测定结肠粘膜SOD、谷胱甘肽过氧化物酶、髓过氧化物酶活性以及过氧化脂质含量,提示SOD的保护作用机理是减少炎症过程中的氧自由基。
This article observed the superoxide dismutase (SOD) mucosal protective effect of acetic acid-induced colitis in rats. In contrast to the saline group, prophylactic intravenous administration of 10,000 USOD significantly reduced the mucosal injury index and the incidence of intestinal adhesion and stenosis. However, intraperitoneal injection of enema with the same dose of SOD and saline control group compared, no significant difference. Mucosal protective effect of SOD was dose-effect. Determination of colonic mucosal SOD, glutathione peroxidase, myeloperoxidase activity and lipid peroxidation, suggesting that the protective mechanism of SOD is to reduce the oxygen free radicals in the inflammatory process.