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本刊讯2015年6月17日,清华大学医学院生物医学工程系高卫平研究组在生物材料学国际顶级期刊上在线发表了题为《位点选择性原位生成的荧光高分子-抗体偶联物通过信号放大提高对抗原的检测灵敏度》的学术论文,报道了他们在抗体-高分子偶联物研究中取得的新进展。该研究创造性地通过化学生物学和高分子化学手段,位点选择性地从单抗的四个链间双硫键上原位高效生长出荧光高分子,所制备的抗体-高分子偶联物不但较好地保留了抗
Jun 17, 2015, Department of Biomedical Engineering, Tsinghua University, Department of Biochemical Engineering Gao Weiping research group in the biomaterials international top journals published online entitled “site selective in situ generation of fluorescent polymer - antibody coupling The article increases the detection sensitivity of antigens by signal amplification ”, and reports on their recent progress in the study of antibody-polymer conjugates. This study creatively through chemical biology and macromolecular chemistry means, site-selective from the four inter-chain disulfide bond of monoclonal antibody efficiently grow fluorescent macromolecules, the prepared antibody - polymer conjugates Not only better preserved anti