This paper considers the boundary stabilization and parameter estimation of a one-dimensional wave equation in the case when one end is fixed and control and harmonic disturbance with uncertain amplitude are input at another end. A high-gain adaptive regulator is designed in terms of measured collocated end velocity. The existence and uniqueness of the classical solution of the closed-loop system is proven. It is shown that the state of the system approaches the standstill as time goes to infinity and meanwhile , the estimated parameter converges to the unknown parameter. This paper considers the boundary stabilization and parameter estimation of a one-dimensional wave equation in the case when one end is fixed and control and harmonic disturbance are uncertain amplitude are input at another end. A high-gain adaptive regulator is designed in terms of measured The existence and uniqueness of the classical solution of the closed-loop system is proven. It shows shown that the state of the system approaches the standstill as time goes to infinity and meanwhile, the estimated parameter converges to the unknown parameter.