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目的探讨原发性高血压与良性前列腺增生(BPH)发生与进展的相关性。方法对临床诊断为BPH,因重度下尿路梗阻接受手术治疗,术后病理证实为BPH的423例患者的临床资料进行分组对比分析。结果423例患者中,BPH合并高血压者128例(303%)。BPH合并高血压组患者的平均手术年龄以及血尿发生率明显大于单纯BPH组(P<005)。在BPH合并高血压组中,平均舒张压≥90mmHg组患者的发病年龄及接受手术治疗的年龄明显比平均舒张压<90mmHg组提前(P<005,P<001)。与单纯BPH组的各项临床指标相比,BPH合并高血压组中10年以上高血压病史患者的BPH发病年龄明显提前(P<005);高血压病史超过20年时尿潴留发生次数明显增加,血尿发生率明显升高,前列腺容积明显增大(P均<005)。BPH合并高血压患者的前列腺容积与高血压病史呈显著正相关(r=0056,P=0009)。结论BPH同时合并高血压多见;长期高血压尤其是高舒张压状态能够促进BPH的发生以及临床进展。
Objective To investigate the relationship between essential hypertension and the occurrence and progression of benign prostatic hyperplasia (BPH). Methods The clinical data of 423 patients with clinically diagnosed BPH, severe lower urinary tract obstruction undergoing surgery, and postoperative pathology confirmed as BPH were grouped and analyzed comparatively. Results Of the 423 patients, 128 (303%) had BPH complicated with hypertension. The average age of surgery and hematuria in BPH patients with hypertension group were significantly higher than those in BPH group (P <0.05). In the BPH combined hypertension group, the age at onset of the mean diastolic blood pressure ≥90mmHg group and the age of the patients undergoing surgery were significantly earlier than the mean diastolic blood pressure <90mmHg group (P <005, P <001). BPH patients with hypertension more than 10 years history of hypertension significantly earlier age (P <005); BPH patients with hypertension history more than 20 years, the incidence of urinary retention increased significantly , The incidence of hematuria increased significantly, prostate volume increased significantly (P <005). There was a significant positive correlation between prostate volume and the history of hypertension in BPH patients with hypertension (r = 0056, P = 0009). Conclusions BPH combined with hypertension is more common. Long-term hypertension, especially high diastolic pressure, can promote the occurrence and clinical progress of BPH.