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报告1例血管内大B细胞淋巴瘤。患者女,63岁。双下肢多发红斑、皮下结节半年余。组织病理显示真皮及皮下脂肪小到中等大血管内可见大量的形态大小较为一致的肿瘤细胞,瘤细胞体积较大。免疫组化结果显示血管内肿瘤细胞CD20、CD79a、B细胞淋巴瘤-2基因(BCL-2)、BCL-6、多发性骨髓瘤癌基因1(MUM1)阳性,CD2、CD3、CD4、CD8、CD30、CD56、穿孔素、颗粒酶、T细胞内抗原(TIA)阴性,Ki-67增殖指数100%,EBV原位杂交阴性。诊断为血管内大B细胞淋巴瘤。
One case of intravascular B-cell lymphoma was reported. Female patient, 63 years old. Multiple lower eyelid erythema, subcutaneous nodules more than six months. Histopathology showed that dermis and subcutaneous fat were small to medium large blood vessels showed a large number of relatively uniform form of tumor cells, tumor cells larger. The results of immunohistochemistry showed that the expression of CD20, CD79a, BCL-2, BCL-6, MUM1, CD2, CD3, CD4, CD8, CD30, CD56, perforin, granzyme, T-cell negative antigen, Ki-67 proliferation index 100%, EBV in situ hybridization negative. Diagnosis of intravascular large B cell lymphoma.