论文部分内容阅读
研究目的探讨格林-巴利综合征(GBS)患者β_2-微球蛋白(β_2-M)和溶菌酶(LZM)的变化。研究设计病例对照研究。研究单位一附院患者和主要参与者 50例GBS患者,男31例,女19例,年龄11～57岁。对照组21例无神经系统疾患的外科小手术患者,男13例,女8例,年龄20～65岁;输血队员24例,男18例,女6例,年龄22～45岁。处理方法用放射免疫法测定β_2-M,用比浊法测定LZM。对结果进行t检验。结果 GBS患者,CSF中的β_2-M急性期较对照组高(P<0.05),恢复期较急性期低(P<0.025),急性期因呼吸衰竭死亡者较存活者增高极为显著(P<0.005)。血清的β_2-M较对照组高(P<0.025)。CSF中的LZM急性期死亡者较存活者增高也极为显著(P<0.0025)。结论 GBS患者的CSF和血清中的β_2-M和LZM与病情的严重程度密切相关。这两种蛋白质之间在血清或CSF中均无相关性。
Objective To investigate the changes of β_2-microglobulin (β_2-M) and lysozyme (LZM) in patients with Guillain-Barre Syndrome (GBS). Study design Case-control study. 50 patients with primary appendage and primary participants in the study unit were 50 GBS patients, 31 males and 19 females, aged from 11 to 57 years. Twenty-one patients without surgical treatment of neurological disorders in the control group were 13 males and 8 females, aged 20-65 years. Twenty-four blood transfusions were included, including 18 males and 6 females, aged 22-45 years. Treatment methods Determination of β_2-M by radioimmunoassay, turbidimetric determination of LZM. The results of t test. Results In the GBS patients, the β_2-M acute phase in CSF was higher than that in the control group (P <0.05), the recovering period was lower than that in the acute phase (P <0.025), and the mortality in the acute phase was significantly higher than that in the survivors (P < 0.005). Serum β_2-M was higher than the control group (P <0.025). CSF death in the acute phase of LZM was also significantly higher than survivors (P <0.0025). Conclusion The levels of β_2-M and LZM in CSF and serum in patients with GBS are closely related to the severity of the disease. There was no correlation between these two proteins in serum or CSF.