体外急性非淋巴细胞白血病(ANLL)细胞系和ANLL 原始细胞半固体培养证明白血病细胞能沿着粒细胞途径分化,但体内 ANLL 的原始细胞能否完全分化为成熟粒细胞尚未明确地肯定.本文应用 DNA 重组技术,提供了关于 ANLL 原始细胞体内分化程序性质的字验室证据。本文研究了两组 ANLL 女病人的血标本。 In vitro acute non-lymphocytic leukemia (ANLL) cell lines and ANLL primitive cell semi-solid cultures demonstrate that leukemia cells can differentiate along the granulocyte pathway, but whether the in vivo progeny of ANLL cells can fully differentiate into mature granulocytes has not been clearly established. The DNA recombination technique provides lexical evidence on the nature of the ANLL primitive cell differentiation program in vivo. This article examines blood samples from two groups of ANLL female patients.