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全身应用环孢菌素 A(CsA)最常见的皮肤副作用之一是与剂量有关的多毛症。约占30%～95%。本研究目的是进一步了解除口服外,在外用和皮下应用 CsA 时对裸鼠毛发生长的刺激作用。用5周龄的雌性裸鼠50只,分为10组:将 CsA 粉剂溶于纯橄榄油,制成0.2%,1.0%,2.0%,2.5%的 CsA 溶液,分别涂在4组裸鼠背部,连续3用。另外按 CsA500mg/kg/d 的剂量溶于0.05ml 橄榄油,分别外用、口服及皮下应用于另3组裸鼠,连续4周。其余3组分别外用、口服及皮下应用橄榄油作为对照。在鼠龄20周时重复 CsA治疗一次。在9月龄时再应用4周。每周从
Systemic Application One of the most common skin side effects of cyclosporin A (CsA) is dose-related hirsutism. About 30% to 95%. The purpose of this study was to further understand the stimulation of hair growth in nude mice, both externally and subcutaneously, in addition to oral administration. Fifty female nude mice of 5 weeks old were divided into 10 groups: CsA powder was dissolved in pure olive oil to make CsA solution of 0.2%, 1.0%, 2.0% and 2.5% , 3 consecutive use. Another dose CsA500mg / kg / d was dissolved in 0.05ml of olive oil, respectively, orally and subcutaneously applied to the other three nude mice for 4 weeks. The remaining three groups were topical, oral and subcutaneous olive oil as a control. CsA treatment was repeated once at 20 weeks of age. Reapply 4 weeks at 9 months of age. From every week