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为了评价育龄期妇女破伤风类毒素 (TT)突击接种的效果 ,并采用血清学回顾性研究探讨TT免疫应答 ,从而为开展育龄期妇女TT常规接种及制定育龄期妇女TT免疫策略提供科学依据。采用间接血凝方法 ,按容量比例概率抽样 ,随机抽取 36 7名 15～ 35岁育龄期妇女测定血清破伤风抗毒素 (TAT)水平。结果显示 ,5 6 %的育龄期妇女具有保护水平TAT(>0 0 1IU/ml) ,TAT几何平均滴度 (GMT)为 0 0 73IU/ml。接种 1针TT后育龄期妇女TAT >0 0 1IU/ml的占 5 0 % ,GMT为 0 0 39IU/ml;接种 2针TT后育龄期妇女TAT >0 0 1IU/ml的占 6 8% ,GMT为 0 14 5IU/ml,37个月后可检测到TAT ;接种 3针TT后育龄期妇女TAT>0 0 1IU/ml的占 90 % ,GMT为 0 5 76IU/ml,37个月后仍可检测到TAT ;育龄期妇女接种TT各剂次的TAT水平差异有显著的统计学意义。不同接种剂次免疫接种间隔、免疫年龄的TAT水平差异无显著统计学意义。建议 :提高重点地区和育龄期妇女中重点人群TT接种率 ;尽快开展TT常规接种 ;确定重点免疫人群策略
To evaluate the effect of tetanus toxoid (TT) rape vaccination in women of childbearing age and to investigate the TT immune response by serological retrospective study, this study may provide a scientific basis for the routine immunization of TT women in childbearing age and the development of TT vaccination strategies for women of childbearing age. Indirect hemagglutination was used to measure the level of TAT in 367 women of childbearing age from 15 to 35 randomly selected according to the probability proportion of capacity. The results showed that 56% of women of childbearing age had the protection level TAT (> 0 0 IU / ml) and the TAT geometric mean titer (GMT) of 0 0 73IU / ml. The percentage of TAT> 0 0 1 IU / ml and 0 0 39 IU / ml GMT of women of childbearing age after inoculation 1-pin TT were 68% GMT was 0 14 5 IU / ml and TAT was detectable after 37 months. 90% of TAT> 0 0 1 IU / ml and 0 5 76 IU / ml GMT after inoculation 3-pin TT women were still TAT can be detected; women of childbearing age were vaccinated TT various doses of TAT levels were significantly different statistically significant. There was no significant difference in TAT levels between different vaccination times and immune age. Recommendations: To increase the TT vaccination rate among key population groups in key areas and women of childbearing age; To carry out routine TT vaccination as soon as possible; To determine the strategies for key immunization groups