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目的:肠道生态失调和细菌移位在晚期肝病患者中较为常见,强有力的证据表明细菌的移位及其代谢产物可以穿过上皮屏障进而促进实验性肝病的进展。本研究目的是探讨在肝脏疾病的早期阶段细菌易位和肠道微生物变化的动力学。方法:结扎胆总管构建胆汁淤积性肝损伤的小鼠模型,注射CCl4构建中毒性肝损伤的小鼠模型。结果:在两种肝损伤模型中,肠道通透性的增加和细菌的移位在肝脏损伤1 d后同时发生,并同时伴有肠
PURPOSE: Etiology and bacterial translocation of the gut are more common in patients with advanced liver disease. There is strong evidence that bacterial translocation and its metabolites can cross the epithelial barrier to further progress in experimental liver disease. The purpose of this study was to investigate the kinetics of bacterial translocation and gut microbial changes in the early stages of liver disease. Methods: To establish a mouse model of cholestatic liver injury by ligating the common bile duct and injecting CCl4 into a mouse model of toxic liver injury. RESULTS: In both models of liver injury, increased intestinal permeability and bacterial translocation occurred concurrently 1 d after liver injury, accompanied by simultaneous intestinal