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近40年来,全球各地相继报道了众多的有关婴儿维生素K(下称vit K)缺乏性出血的文章,尤其是迟发性vitK缺乏性颅内出血是一严重威胁婴儿生命的中枢神经系统性疾病。患儿仅1/4治愈,幸存者多留有神经系统后遗症。复习近年来国外有关本病的研究及其临床的重要性,简要综述如下。一、历史自1894年由Townsed首次使用新生儿出血性疾病(HDN)一词以来,随后1929年Dam在无脂饮食的鸡中发现vitK缺乏时的出血现象,直至30年代才证实HDN与vitK缺乏有关。50年代初发现HDN在母奶喂养中非常突出,用vitK后能迅速纠
In the past 40 years, many reports on infantile vitamin K deficiency (hereinafter referred to as vit K) have been reported all over the world. In particular, delayed vitK deficiency intracranial hemorrhage is a serious central nervous system disease which threatens the life of infants. Only 1/4 of children cured, leaving survivors more nervous system sequelae. Review of foreign studies in recent years on the disease and its clinical importance, a brief overview is as follows. I. History Since the first use of the word “neonatal hemorrhagic disease” (HDN) by Townsed in 1894, Dam found bleeding in VitK-deficient chickens in a fat-free diet in 1929 and did not confirm HDN and vitK deficiency until the 1930s related. Early 50s found that HDN is very prominent in breastfeeding, with vitK can quickly correct