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目的了解东莞市各种疫苗预防接种异常反应的发生情况,评价东莞市疑似预防接种异常反应(AEFI)监测和处理控制系统的运行状况,方法对该系统2005～2007年所收集的AEFI病例进行描述性分析。结果全市共报告AEFI 569例,其中一般反应272例(47.80%),异常反应267例(46.92%),偶合症18例(3.16%),不明原因7例(1.23%),心因性反应4例(0.70%),实施差错事故1例(0.18%)。男性报告数多于女性。在所使用的24种疫苗中有20种出现不良反应,报告平均发生率为4.19/10万,以肺炎疫苗、HIB和百白破的发生率最高,且百白破的报告数最多。在报告的预防接种不良反应中,最常见的为过敏性皮疹、发热和局部红肿浸润反应。结论该系统在评价疫苗的安全性,发现AEFI发生的危险因素,改善预防接种服务质量起着重要作用。
Objective To understand the incidence of abnormal vaccination in various vaccines in Dongguan and to evaluate the operation status of AEFI monitoring and treatment control system in Dongguan City. Methods AEFI cases collected from 2005 to 2007 in this system were described Sexual analysis. Results A total of 569 AEFI cases were reported in the city, including 272 cases of general reaction (47.80%), 267 cases of abnormal reaction (46.92%), 18 cases of intercourse (3.16%), 7 cases of unexplained cause (1.23%), Cases (0.70%), the implementation of error accident in 1 case (0.18%). Men report more than women. Of the 24 vaccines used, 20 were adversely affected, with an average reported rate of 4.19 / 100,000, with the highest incidence of pneumonia vaccine, HIB and diphtheria, and the highest reported incidence of diphtheria. Among the reported adverse effects of vaccination, the most common are allergic rash, fever and local infiltration of inflamed reactions. Conclusion The system plays an important role in evaluating the safety of vaccines, finding out the risk factors of AEFI and improving the quality of vaccination services.