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大黄有显著的解热效果,退热作用与机体的能量代谢有密切关系。本实验观察了大黄对供能代谢的重要指标 Na~+、K~+-ATP 酶及氧化磷酸化的影响。材料与方法药物:青海西宁产大黄,用15倍蒸馏水浸泡两次,每次30min,煮沸20min 过滤,水浴浓缩提取液,使水提液含生药量为0.5g/ml,再用鸡蛋清除去鞣质,至血凝阴性备用。实验动物:用昆明种小鼠,体重18～20g。本院动物室提供。动物随机分为对照组和三个剂量(分别为2.5g/kg、6.25g/kg、12.5g/kg)组。给药组每日口服大黄水煎剂1次,连续7天。
Rhubarb has a significant antipyretic effect, and its antipyretic effect is closely related to the body’s energy metabolism. In this experiment, we observed the effects of rhubarb on Na+, K+-ATPase and oxidative phosphorylation, an important index of energy metabolism. Materials and Methods Drugs: Rhubarb, Xining, Qinghai, soaked twice with 15 times distilled water, 30min each time, boiled for 20min, filtered, water bath concentrated extract, so that the amount of water extract containing crude drug 0.5g/ml, and then remove the eggs to remove Quality, to hemagglutination negative spare. Experimental animals: Kunming mice were used, weighing 18 to 20 g. The hospital animal room provides. The animals were randomly divided into a control group and three dose groups (2.5 g/kg, 6.25 g/kg, 12.5 g/kg, respectively). The treatment group received rhubarb decoction once daily for 7 days.