细胞自噬是一种通过降解蛋白质和细胞器维持细胞内平衡的细胞机制。细胞自噬具有很多重要的生理功能,包括清除病原体的感染。但是由于细胞自噬在进化过程中具有高度的保守性,某些病原体通过进化,具有逃避细胞自噬的能力,甚至利用细胞自噬为病原体复制和发育提供有利条件。本文综述了细胞自噬与病原体相互作用的研究进展。 Autophagy is a cellular mechanism that maintains intracellular homeostasis by degrading proteins and organelles. Autophagy has many important physiological functions, including clearance of pathogens. However, due to the high degree of conservation of cell autophagy in the evolutionary process, some pathogens evolve, have the ability to evade cell autophagy, and even use cell autophagy to provide favorable conditions for pathogen replication and development. This review summarizes the research progress of the interaction between autophagy and pathogens.