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1 先导化合物最优化仍是新药发现的重要瓶颈 所谓“先导化合物最优化”(leadoptimization)是指药物发现过程中的一个阶段 ,在这个阶段 ,将通过“高通量筛选”(high throughputscreening ,HTS)所产生的有可能作为早期先导化合物的数目 ,减少到可以进行体外和动物实验以优化其
1 Leading compound optimization remains a significant bottleneck in new drug discovery Leadoptimization refers to a phase in the drug discovery process through which high throughput screening (HTS) The resulting potential to act as early lead compounds is reduced to the extent that both in vitro and animal experiments can be performed to optimize