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目的 探讨前列腺素E1(PGE1)对慢性肾炎 (CGN)的治疗效果。方法 PGE110 0 μg加入 5%葡萄糖液 2 50ml中静滴 ,每日 1次 ,共 14～ 2 1d。结果 33例CGN患者经PGE1治疗后 ,血尿素氮 (BUN)由16.2 9± 1.4 3mmol/L下降至 11.0 7± 0 .96mmol/L(P <0 .0 1) ;血肌酐 (SCr)由 4 4 9.38± 145.78μmol/L下降至355.60± 139.0 9μmol/L(P <0 .0 1) ;内生肌酐清除率 (CCr)由 18.75± 13.4 9ml/min升至 2 8.38± 2 0 .74ml/min(P <0 .0 1) ;2 4h尿蛋白由 1.77± 1.0 8g/d降至 0 .96± 0 .76g/d(P <0 .0 1) ;尿红细胞由 3.38± 2 .77万个 /ml下降至 2 .2 3± 1.67万个 /ml(P <0 .0 5) ;尿量由 1.34± 0 .56L/d增加至 1.75± 0 .4 2L/d(P <0 .0 1)。结论 PGE1可改善CGN患者的肾功能 ,减少尿蛋白及血尿 ,对延缓CGN的病情进展有一定的好处
Objective To investigate the therapeutic effect of prostaglandin E1 (PGE1) on chronic nephritis (CGN). Methods PGE110 0 μg added 5% glucose solution 2 50ml intravenous infusion, once daily for a total of 14 ~ 21d. Results The blood urea nitrogen (BUN) decreased from 16.29 ± 1.4 3mmol / L to 11.0 7 ± 0.96mmol / L (P <0.01) in 33 patients with CGN after PGE1 treatment. Serum creatinine (SCr) 4 9.38 ± 145.78μmol / L to 355.60 ± 139.0 9μmol / L (P <0.01); the creatinine clearance rate (CCr) increased from 18.75 ± 13.4 9ml / min to 2 8.38 ± 20.74ml / min (P <0.01). Urinary protein decreased from 1.77 ± 1.08g / d to 0.96 ± 0.76g / d (P <0.01) at 24 hours. Urinary red blood cells increased from 3.38 ± 2.777 / ml to 2.23 ± 16.77 / ml (P <0.05); urine output increased from 1.34 ± 0.56 L / d to 1.75 ± 0.42 L / d (P <0.01) ). Conclusions PGE1 can improve renal function, reduce urinary protein and hematuria in patients with CGN, and have some benefits on the progression of CGN