Regulation of Cued Fear Expression via Corticotropin-Releasing-Factor Neurons in the Ventral Anterom

来源 :神经科学通报(英文版) | 被引量 : 0次 | 上传用户:wan6415383aa
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
The ventral part of the anteromedial thalamic nucleus(AMv)is in a position to convey information to the cortico-hippocampal-amygdalar circuit involved in the processing of fear memory.Corticotropin-releasing-factor(CRF)neurons are closely associated with the regulation of stress and fear.However,few studies have focused on the role of thalamic CRF neurons in fear memory.In the present study,using a conditioned fear paradigm in CRF transgenic mice,we found that the c-Fos protein in the AMv CRF neurons was significantly increased after cued fear expression.Chemogenetic activation of AMv CRF neurons enhanced cued fear expression,whereas inhibition had the opposite effect on the cued fear response.Moreover,chemogenetic manipulation of AMv CRF neurons did not affect fear acquisition or contextual fear expression.In addition,anterograde tracing of projections revealed that AMv CRF neurons project to wide areas of the cerebral cortex and the limbic system.These results uncover a critical role of AMv CRF neurons in the regulation of conditioned fear memory.
其他文献
二、怎么教的问题工业设计高等职业技术教育的工作目标,是培养毕业后能很快进入设计市场,能设计出比市售商品高一个档次产品的实际设计人才。本观点可能过于朴素,但却是基于
鸡西矿业集团公司张辰煤矿西三采区3
期刊
“2010宜兴紫砂名家云南行暨作品捐赠”公益活动在云南省博物馆开幕,来自“紫砂之都”宜兴的十把紫砂壶精品首次正式落户省博。 “2010 Yixing purple Zisha Yunnan line a
磨损是冲裁模具常见的一种失效形式,以预减振盖板零件为分析对象,利用Pro/E软件建立板料冲裁的几何模型,应用Deform-2D模拟软件对板料的冲裁过程进行有限元仿真,分析了冲裁过
录像机是现代计算机技术、电子技术与精密机械有机结合的产品。它的突出特点是各项操作实现了智能化,因此,不仅电路部分较复杂,而且机械部分与其他家用电器相比也要复杂得多
Migraine is a common and debilitating headache disorder.Although its pathogenesis remains elusive,abnormal trigeminal and central nervous system activity is lik
本文通过对暴露于氯乙烯作业工人的调查,发现接触组氨己糖(AH)、羟脯氨酸(HP)、肝胆酸(CG)、总巯基(MG)等生化指标和对照组比较差异存在显著意义。 In this paper, the expo
目的:探讨湖北地区人群成纤维细胞生长因子受体-2基因(FGFR2)第2内含子单核苷酸多态性(SNP)与乳腺癌易感性的关系。方法:采用PCR及DNA测序方法,对汉族204例女性乳腺癌患者(乳
请下载后查看,本文暂不支持在线获取查看简介。李政作品 Please download to view, this article does not support online access to view profile. Li Zheng works
期刊
山花烂i去山司旨.,州二矍滚撇辍翼漓江春早侣声,之工,r月名;秋山行I旦二二刁目人石r,,竹林七肾图1 43 x 237em秋山行I旦二二刁目人石r,,竹林七肾图1 43 x 237em秋山行I旦二二