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Artemin是胶质细胞源性神经营养因子(gilal cellline derived neurotrophic factor,CDNF)家族中的一个成员,同时也是转化生长因子-β(transforming growth factor-β,TGF-β)超家族中的一个亚型。Artemin通过GDNF受体转导信号调控肿瘤的生长,Artemin参与了胰腺癌、食管癌等消化道肿瘤的发生、发展,并与胰腺癌的嗜神经侵袭密不可分。Artemin可以提高子宫内膜癌、乳腺癌等生殖系统肿瘤细胞的致癌性和侵袭力,降低癌细胞对化疗药物的敏感度。Artemin还在鳞状细胞肺癌和内分泌腺瘤等肿瘤的生长调控中发挥了重要作用,降低Artemin的表达水平可有效抑制肿瘤生长和转移。Artemin有望成为肿瘤诊疗的新靶点。
Artemin is a member of the glandular cell line derived neurotrophic factor (CDNF) family and is a subtype of the transforming growth factor-β (TGF-β) superfamily . Artemin regulates tumor growth through GDNF receptor transduction signals. Artemin is involved in the development and progression of gastrointestinal cancers such as pancreatic cancer and esophageal cancer, and is closely linked to the neurotoxicity of pancreatic cancer. Artemin can increase the carcinogenicity and invasiveness of reproductive system tumor cells such as endometrial cancer and breast cancer and reduce the sensitivity of cancer cells to chemotherapeutic drugs. Artemin also plays an important role in the regulation of tumor growth in squamous cell lung cancer and endocrine adenomas. Reducing Artemin expression can effectively inhibit tumor growth and metastasis. Artemin is expected to be a new target for cancer treatment.