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目的探讨环氧化酶-2(COX2)的表达与大肠癌侵袭和转移的关系。方法采用免疫组化法检测44例大肠癌患者肠黏膜标本中COX2的表达情况。结果 COX2的表达在不同TNM的分期组、有无浆膜浸润组及有无淋巴结转移组中差异均有统计学意义(P<0.01)。结论 COX2表达与大肠癌侵袭、转移呈正相关,其表达增加提示大肠癌有较高的恶性生物学行为。
Objective To investigate the relationship between cyclooxygenase-2 (COX2) expression and invasion and metastasis of colorectal cancer. Methods Immunohistochemistry was used to detect the expression of COX2 in 44 cases of colorectal cancer. Results The expression of COX2 in different TNM staging groups, with or without serosal invasion and lymph node metastasis were significantly different (P <0.01). Conclusions The expression of COX2 is positively correlated with the invasion and metastasis of colorectal cancer. The increased expression of COX2 suggests that colorectal cancer has high malignant biological behavior.