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冠心病是最常见的心脏疾病,也是导致死亡的主要疾病,其病理基础是动脉粥样硬化。淋巴毒素α是重要的前炎性因子,参与趋化因子的释放、细胞之间的黏附和聚集等,在动脉粥样硬化的发生发展中起重要作用。半乳凝素2参与淋巴毒素α的分泌过程,降低其表达水平可能会减弱动脉炎性过程。本文就淋巴毒素α及半乳凝素2与冠心病的关联研究进展予以综述。
Coronary heart disease is the most common heart disease, is also the leading cause of death disease, the pathological basis of atherosclerosis. Lymphotoxin α is an important pro-inflammatory factor involved in the release of chemokines, cell adhesion and aggregation, play an important role in the development of atherosclerosis. Galectin-2 is involved in the secretion of lymphotoxin a and decreasing its expression level may attenuate arterial inflammatory processes. This article reviews the progress of lymphatic toxin alpha and galectin-2 in relation to coronary heart disease.