目的：评价米非司酮配伍与不配伍甲基睾丸素治疗子宫肌瘤的临床效果。方法：有症状的子宫肌瘤患者６０例，随机分为两组，每组３０例。Ａ组：口服米非司酮及甲基睾丸素。米非司酮２５ｍｇ，甲基睾丸素５ｍｇ，每日１次，连服９０天；Ｂ组：口服米非司酮及安慰剂，服药方法同Ａ组。结果：两组治疗后均使患者发生闭经。Ａ组治疗后经量减少４９３２％，瘤体缩小５２２０％；Ｂ组治疗后经量减少３９８０％，瘤体缩小４４１０％。结论：抗雌孕激素的联合治疗是保守性治疗子宫肌瘤较为理想的方法。 Objective: To evaluate the clinical effect of mifepristone compatibility and non-match methyltestosterone in the treatment of uterine fibroids. Methods: Sixty patients with symptomatic uterine fibroids were randomly divided into two groups, 30 in each group. Group A: oral mifepristone and methyl testosterone. Mifepristone 25mg, methyltestosterone 5mg, once daily, and even served 90 days; group B: Oral mifepristone and placebo, medication method with the A group. Results: Both patients had amenorrhea after treatment. In group A, the amount of meridian was reduced by 4932% after treatment, and the tumor size was reduced by 5220%. After treatment, the volume of treatment in group B was decreased by 3980%, and the tumor size was reduced by 4410%. Conclusion: The combination of anti-progesterone and progesterone therapy is an ideal method for conservative treatment of uterine fibroids.