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目的 探讨胰岛素加二甲双胍治疗磺脲类药物失效 2型糖尿病的疗效。方法 将 43例磺脲类药物失效 2型糖尿病患者随机分为观察组 ( 2 3例 )和对照组 ( 2 0例 ) ,观察组在对照组常规治疗基础上加口服二甲双胍。结果 观察组治疗结束时的满意控制率达 83 % ( 19/ 2 3 ) ,对照组为 5 5 % ( 11/ 2 0 ) ,观察组的胰岛素敏感性指数比对照组明显增加 ,胰岛素用量比对照组明显减少 ,而且无出现低血糖反应病例。结论 胰岛素加二甲双胍是治疗磺脲类药物失效 2型糖尿病的一种安全、有效的方法。
Objective To investigate the efficacy of insulin plus metformin in the treatment of type 2 diabetes mellitus with sulfonylurea failure. Methods 43 cases of type 2 diabetes mellitus with sulfonylurea failure were randomly divided into observation group (23 cases) and control group (20 cases). The observation group was given metformin orally on the basis of conventional treatment. Results In the observation group, the satisfactory control rate reached 83% (19/23) at the end of treatment and 55% (11/20) in the control group. The insulin sensitivity index in the observation group was significantly higher than that in the control group, Group significantly reduced, but no cases of hypoglycemia. Conclusion Insulin plus metformin is a safe and effective method for the treatment of type 2 diabetes mellitus with sulfonylureas failure.