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1目的 探讨镁在新生儿低氧缺血性脑损伤中的治疗价值。 2方法 采用随机对照法 ,对 76例新生儿缺氧缺血性脑病 (HIE)进行治疗研究 ,对照组 38例给予一般常规综合治疗 ,治疗组 38例在此基础上每天加用2 5 0 g/ L硫酸镁注射液 0 .1m L / kg体质量。3结果 治疗组治疗后临床症状消失时间为 (3.8± 1.3) d,对照组 (6 .2±1.7) d,两组比较差异有极显著意义 (t=6 .6 7,P <0 .0 1) ;治疗组治疗后 10 d脑 CT检查脑组织恢复正常率为47.2 % ,明显高于对照组的 2 2 .8% ,差异有显著性 (χ2 =4.6 2 ,P<0 .0 5 ) ;治疗组血清肌酸激酶脑型同工酶 (CK- BB)活性为 (6 .2 1± 1.83) U/ L ,对照组为 (11.2 6± 2 .14) U / L ,两组比较差异有极显著性 (t=10 .74,P<0 .0 1) ;血清钙、镁浓度治疗组分别为 (2 .16± 0 .2 4) m mol/ L ,(0 .91± 0 .13) m mol/ L ,对照组为 (1.82± 0 .2 1) mmol/ L ,(0 .6 8± 0 .12 )mm ol/ L ,两组比较差异有极显著性 (t=6 .42 ,7.72 ,P<0 .0 1)。治疗组无 1例出现硫酸镁不良反应。 4结论 小剂量硫酸镁治疗 HIE是一简便、安全、有效的方法
1 Objective To investigate the therapeutic value of magnesium in neonatal hypoxic-ischemic brain damage. 2 Methods Randomized controlled study of 76 neonates with hypoxic-ischemic encephalopathy (HIE) for the treatment of study, the control group of 38 patients given conventional general treatment, the treatment group 38 patients on the basis of this daily plus 250 g / L magnesium sulfate injection 0 .1m L / kg body weight. 3 Results After treatment, the disappearance time of clinical symptoms in the treatment group was (3.8 ± 1.3) days and in the control group (6.2 ± 1.7 days), there was significant difference between the two groups (t = 6.76, P <0. 0 1). The recovery rate of brain tissue in the treatment group 10 days after treatment was 47.2%, significantly higher than that of the control group (22.8%) (χ2 = 4.6 2, P <0.05) The serum creatine kinase (CK-BB) activity of the treatment group was (6.21 ± 1.83) U / L and that of the control group was (11.26 ± 2.14) U / L, (T = 10.74, P <0.01). The levels of serum calcium and magnesium in the treatment group were (2.16 ± 0.24) m mol / L, (0 .91 ± 0. (1.82 ± 0.21 mmol / L, (0.08 ± 0.12) mm ol / L, respectively. There was significant difference between the two groups (t = 6). 42, 7.72, P <0.01). None of the patients in the treatment group had adverse reactions of magnesium sulfate. 4 Conclusion Small doses of magnesium sulfate treatment of HIE is a simple, safe and effective method