【摘 要】
：
One of the grand strategies in the development of the nervous system is to overproduce constructive elements and then selectively to prune the excess,for example,by synaptic pruning.Given limited resources,surviving synapses are nurtured and reinforced,wh
【机 构】
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State Key Laboratory of Organ Failure Research,Key Laboratory of Mental Health of the Ministry of Ed
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One of the grand strategies in the development of the nervous system is to overproduce constructive elements and then selectively to prune the excess,for example,by synaptic pruning.Given limited resources,surviving synapses are nurtured and reinforced,while the unsuccess-ful synapses are eliminated.Synaptic pruning also persists in the mature nervous system via activity-dependent plasticity,which is crucial for learning and memory.To assemble refined mature neuronal circuits and maintain homeostasis,synaptic pruning must proceed in a controlled and timely manner.Aberrant synaptic pruning may lead to neurodevelopmental disorders,such as autism,schizophre-nia,and epilepsy [1].
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