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目的:探讨前列地尔(PGE1)联合美卡素在治疗早期糖尿病肾病(DN)中的临床疗效。方法:收集本院住院63例早期DN患者,随机分为单纯PGE1组21例,单纯美卡素组21例,联合用药组21例,进行4周临床观察治疗,分别比较三组血糖、尿素氮、血肌酐、尿肌酐、24h尿蛋白定量、尿白蛋白水平的变化。结果:治疗4周后,各组24h尿蛋白定量及尿白蛋白等指标都较治疗前均有明显好转(P<0.01);而联合组的24h尿蛋白定量及尿白蛋白较另两组改善更显著(P<0.01)。结论:前列地尔联合美卡素治疗早期DN,能有效的发挥不同机理的协同作用,减少尿蛋白,更有助于延缓DN向中末期肾病发生和发展。
Objective: To investigate the clinical efficacy of prostaglandin (PGE1) combined with mecamyzin in the treatment of early diabetic nephropathy (DN). Methods: Sixty-three inpatients with early-stage DN were enrolled in this study. They were randomly divided into PGE1 group (21 cases), mecamyllin group (21 cases) and combination group (21 cases) , Serum creatinine, urinary creatinine, 24h urinary protein, urinary albumin levels. Results: After 4 weeks of treatment, the 24-hour urinary protein excretion and urinary albumin index in each group were significantly improved compared with those before treatment (P <0.01); while in the combined group, 24h urinary protein and urinary albumin were improved compared with the other two groups More significant (P <0.01). Conclusion: Alprostadil combined with meclofenac treatment of early DN, can effectively play a synergistic effect of different mechanisms to reduce urinary protein, but also help to delay the occurrence of DN to the development of end-stage renal disease and development.