氨基糖苷类抗生素常与青霉素类合并给药,对治疗某些感染性疾病具有协同作用.众所周知,氨基糖苷类抗生素可与青霉素类发生反应.关于氨基糖苷类抗生素的分解已有报道,然而,涉及到氨基糖苷类对青霉素类的影响问题,除有1份报告外,说明在混合液中反倒使羧苄青霉素活性有所损失者,几乎还没有可取的报告资料.本文报道托普霉素对羧苄青霉素二钠稳定性的影响用磷酸盐缓冲液(pH6.6)、5%葡萄糖和0.9%氯化钠注射液,配成不同浓度的托普霉素(40～160μg/ml)与羧苄青霉素二钠(100～1000μg Aminoglycoside antibiotics are often combined with penicillins and have synergistic effects in the treatment of certain infectious diseases.It is known that aminoglycoside antibiotics can react with penicillins.About the decomposition of aminoglycoside antibiotics has been reported, however, To aminoglycosides on penicillins impact, in addition to a report, indicating that in the mixture of carbbenzamide but the loss of activity, almost no desirable data reported.Topromycin reported carboxylate The effect of benzylpenicillin disodium stability with phosphate buffer (pH6.6), 5% glucose and 0.9% sodium chloride injection, dubbed the different concentrations of tobramycin (40 ~ 160μg / ml) and carbobenzyl Penicillin disodium (100 ~ 1000μg