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目的观察复方莲柏雾化剂以雾化吸入作为给药方式治疗复发性阿弗他溃疡(recurrent aphtha ulcer,RAU)的疗效。方法将276例RAU患者随机分为观察组和对照组,各138例。观察组给予自制复方莲柏雾化剂(成分:莲子心50 g,黄柏150 g,生地200 g,竹叶150 g,白矾25 g,甘草50 g,硫糖铝)雾化吸入,对照组口服维生素C、维生素B2、奥硝唑。5 d为1疗程,均治疗1个疗程。结果临床追踪观察,3例失访者排除(观察组2例,对照组1例),观察组与对照组总有效率比较差异有统计学意义(88.2%vs 74.5%,P<0.05);经180 d以上随访,观察组治疗后复发周期明显较治疗前和对照组治疗后延长(P均<0.05);治疗后,观察组溃疡大小、溃疡数目、充血程度及疼痛程度与对照组比较明显好转(P均<0.05)。结论复方莲柏雾化剂治疗RAU无毒副作用,方便易行,疗效确切。
Objective To observe the curative effect of compound Lianbai nebulizer in the treatment of recurrent aphtha ulcer (RAU) with nebulized inhalation as the administration mode. Methods 276 patients with RAU were randomly divided into observation group and control group, 138 cases each. The observation group was given the inhalation of self-made Lianbai atomizer (composition: lotus heart 50 g, cork 150 g, habitat 200 g, bamboo leaves 150 g, alum 25 g, licorice 50 g, sucralfate) Vitamin C, vitamin B2, ornidazole. 5 d for a course of treatment, are treated with a course of treatment. Results The clinical follow-up was observed in 3 cases (2 cases in observation group and 1 case in control group). The total effective rate in observation group and control group was significantly different (88.2% vs 74.5%, P <0.05) After 180 days of follow-up, the recurrence period of the observation group was significantly longer than that of the control group before and after treatment (P <0.05). After treatment, the ulcer size, the number of ulcers, the extent of congestion and the degree of pain in the observation group were significantly improved compared with the control group (P <0.05). Conclusion Compound Lianbai atomizer RAU non-toxic side effects, easy to operate, the exact effect.