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氨基糖苷类抗生素对革兰氏阴性杆菌有强大的杀菌力,在消化道外科所使用的抗生素制剂中占有重要的位置。然而,这类抗生素的中毒剂量和有效剂量之间的差值甚小,属于治疗域狭小的药物,必须监测血液浓度,并慎重使用。这类抗生素的体内动态,受着病人肾功能等重要原因的影响。在消化道外科领域,多数是在手术后用药,并往往被设想为在术后的早期,抗生素的体内动态和健康状态下的不相同。为了获知术后正确的用药方法,作者以健康志愿者和消化道外科术后病人为对象,检查和比较肌肉注射或静脉注射时血中浓度,并讨论对术后病人用药时对肾功能的影响。
Aminoglycoside antibiotics have a strong bactericidal effect on Gram-negative bacilli and occupy an important place in the antibiotic preparations used in gastrointestinal surgery. However, the difference between the toxic dose and the effective dose of such antibiotics is very small, belong to the narrow therapeutic area of the drug, the blood concentration must be monitored and used with caution. The dynamics of such antibiotics in vivo are influenced by important reasons such as the patient’s renal function. In the field of gastrointestinal surgery, most are treated postoperatively and are often assumed to be different in the early postoperative period, in vivo dynamics and health status of the antibiotic. In order to know the correct method of postoperative medication, the authors examined healthy volunteers and postoperative patients with gastrointestinal surgery for the purpose of examining and comparing intramuscular or intravenous blood concentrations and discussing the effects on the renal function of postoperative patients .