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[目的]观察胃复春联合三联疗法(枸橼酸铋雷尼替丁片、阿莫西林分散片、克拉霉素缓释片)对幽门螺杆菌(Hp)阳性胃溃疡的临床疗效,及对Hp根除率、胃泌素(GAS)、胃动素(MTL)的影响。[方法]将Hp阳性的胃溃疡患者176例随机分为两组,治疗组92例、对照组84例。对照组使用三联疗法,治疗组在对照组基础上加服胃复春;服药10天后,对照组单独口服枸橼酸铋雷尼替丁片4周;治疗组在服用枸橼酸铋雷尼替丁片基础上加服胃复春片4周。观察两组的临床疗效、Hp根除率、胃泌素、胃动素水平。[结果]治疗组总有效率95.65%,优于对照组,差异有统计学意义(P<0.05);治疗组Hp根除率91.30%,优于对照组,差异有统计学意义(P<0.05);治疗组治疗后胃泌素水平低于治疗前水平,亦低于对照组治疗后水平,其差异均有统计学意义(P<0.05)。[结论]胃复春联合三联疗法抗Hp治疗方案能有效根除幽门螺杆菌,降低胃泌素水平,对幽门螺杆菌阳性胃溃疡能起到较好的治疗效果。
[Objective] To observe the clinical efficacy of Weifuchun combined with triple therapy (ranitidine bismuth citrate tablets, amoxicillin dispersible tablets and clarithromycin sustained-release tablets) on Helicobacter pylori (Hp) -positive gastric ulcer Hp eradication rate, gastrin (GAS), motilin (MTL). [Method] 176 patients with Hp-positive gastric ulcer were randomly divided into two groups: treatment group (n = 92) and control group (n = 84). In the control group, triple therapy was used. In the control group, gastric re-treatment was given on the basis of the control group. In the control group, ranitidine citrate bismuth alone was given orally for 10 days after taking the medicine for 4 weeks. The treatment group took ranitidine bismuth citrate On the basis of Ding added gastric rejuvenation tablets for 4 weeks. The clinical efficacy, Hp eradication rate, gastrin, and motilin levels in both groups were observed. [Result] The total effective rate of the treatment group was 95.65%, which was better than that of the control group (P <0.05). The eradication rate of Hp in the treatment group was 91.30%, which was better than that of the control group (P <0.05) The level of gastrin in the treatment group was lower than that before treatment and lower than that in the control group after treatment. The difference was statistically significant (P <0.05). [Conclusion] Weifuchun combined with triple therapy anti-Hp treatment can effectively eradicate Helicobacter pylori, reduce gastrin level and have good therapeutic effect on Helicobacter pylori positive gastric ulcer.