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目的:血清中的前列腺特异性抗原(t-PSA)、游离PSA(f-PSA)及f/t-PSA在前列腺增生与前列腺癌鉴别诊断中的意义。方法:应用放射免疫法检测89例前列腺增生与前列腺癌患者血清中的特异性抗原、游离PSA,并计算f/t-PSA比值。结果:血清PSA在4ng/ml～10ng/ml时,前列腺增生与前列腺癌组的特异性抗原含量差异无显著性(P>0.05),游离PSA、f/t-PSA比值差异具有显著性(P<0.05)。结论:在前列腺增生(BPH)和前列腺癌(PCA)诊断灰区,同时检测游离PSA、特异性抗原,并应用f/t-PSA比值诊断前列腺癌明显优于单纯使用特异性抗原,是早期诊断前列腺癌的新参数,不但提高了前列腺癌的检出率,并减少了不必要的前列腺穿刺活检对患者造成的创伤和痛苦。
Objective: To investigate the significance of serum t-PSA, f-PSA and f / t-PSA in differential diagnosis of prostatic hyperplasia and prostate cancer. Methods: 89 cases of benign prostatic hyperplasia and prostatic cancer were detected by radioimmunoassay in patients with serum specific antigen, free PSA, and calculate the f / t-PSA ratio. Results: There was no significant difference in PSA between 4ng / ml and 10ng / ml (P> 0.05), while there was no significant difference between PSA and f / t-PSA <0.05). Conclusions: It is an early diagnosis that BPH and PCA diagnose gray areas, detect free PSA and specific antigen simultaneously, and diagnose prostate cancer with f / t-PSA ratio is superior to purely using specific antigens New parameters of prostate cancer not only improve the detection rate of prostate cancer, but also reduce the trauma and pain caused to patients by unnecessary prostate biopsy.