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目的:探讨山莨菪碱、肝素联合股动脉注射治疗早期糖尿病下肢血管病变的疗效。方法:80例经彩色多普勒检查诊断为糖尿病下肢血管病变的糖尿病患者,给予山莨菪碱10mg、肝素50mg加生理盐水5ml股动脉注射,每天1次,10次为1个疗程后,再予以彩色多普勒复查,对治疗前后超声数据进行统计分析。结果:治疗后患者下肢麻木、疼痛及足凉等症状减轻或消失,彩色多普勒复查显示血流动力学指标明显改善,下肢动脉的内径增宽、频谱变窄及加速度/减速度比值减小(P<0.01)。结论:山莨菪碱、肝素联合股动脉注射治疗糖尿病下肢血管病变疗效确切、安全、经济、实用,无明显毒副作用,值得推广应用。
Objective: To investigate the curative effect of anisodamine and heparin combined with femoral artery in the treatment of lower extremity vascular disease in early stage of diabetes. Methods: Eighty diabetic patients diagnosed with diabetic lower extremity vascular disease by color Doppler were given anisodamine 10mg, heparin 50mg and normal saline 5ml femoral artery injection once a day for 10 times for one course of treatment and then given Color Doppler review, before and after treatment of ultrasound data for statistical analysis. Results: The symptoms such as numbness, pain and coldness in the lower limbs of the patients after treatment were alleviated or disappeared. Color Doppler examination showed significant improvement of hemodynamics, broadening of the diameter of the lower extremity arteries, narrowing of the spectrum and decreasing of the acceleration / deceleration ratio (P <0.01). Conclusion: Anisodamine and heparin combined with femoral artery injection is effective, safe, economical and practical for the treatment of diabetic lower extremity vascular diseases. It is worth to be popularized and applied.