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目的探讨草酸铂联合氟脲嘧啶及亚叶酸钙治疗晚期大肠癌的疗效和毒性反应。方法22例晚期大肠癌患者应用联合方案化疗,草酸铂120mg/m2,第1天;亚叶酸钙200mg/m2,第1~5天;氟脲嘧啶500mg/m2,第1~5天。3周为1个周期。结果22例中CR 2例,PR 7例,NC 10例,PD 3例,总有效率(CR+PR)为41%。主要不良反应为骨髓抑制、消化道反应和感觉神经毒性,多为Ⅰ~Ⅱ度。结论草酸铂联合氟脲嘧啶及亚叶酸钙治疗晚期大肠癌疗效肯定,不良反应轻。
Objective To investigate the efficacy and toxicity of oxaliplatin plus fluorouracil and leucovorin in the treatment of advanced colorectal cancer. Methods 22 patients with advanced colorectal cancer were treated with combination regimen of chemotherapy with oxaliplatin 120 mg / m2 on day 1; leucovorin 200 mg / m2 on day 1 to 5; and fluorouracil 500 mg / m2 on day 1 to 5. 3 weeks for 1 cycle. Results Among 22 cases, 2 were CR, 7 were PR, 10 were NC and 3 were PD. The total effective rate (CR + PR) was 41%. The main adverse reactions were myelosuppression, gastrointestinal reactions and sensory neurotoxicity, mostly Ⅰ ~ Ⅱ degrees. Conclusions Oxaliplatin plus fluorouracil and leucovorin are effective in the treatment of advanced colorectal cancer with mild adverse reactions.