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目的:观察利巴韦林、炎琥宁治疗婴幼儿轮状病毒肠炎的临床疗效。方法:将我院诊疗的婴幼儿轮状病毒肠炎患者236例随机分为利巴韦林组(A组)、炎琥宁组(B组)、对照组(C组),再按入院时距发病时间分为病程0-48 h组,病程>48 h组。C组仅给予补液、维持水电解质平衡等基础治疗;A组加用利巴韦林(10-15)ng/(kg·d)静脉滴注,B组加用炎琥宁(5-8)mg/(kg·d)静脉滴注,比较各组患儿发热持续时间、退热时间、腹泻性状及次数恢复正常时总病程时间。结果:在病程0-48 h组中,A组、B组的退热时间均明显短于C组,B组总病程明显短于C组,P均<0.05;在病程>48 h组中,A组、B组、C组退热时间均无明显差异,B组总病程短于A组、C组。结论:在起病0-48 h间使用利巴韦林、炎琥宁有助于轮状病毒肠炎患者退热,使用炎琥宁可缩短病程,有助于改善腹泻症状。
Objective: To observe the clinical efficacy of ribavirin and mesylate in the treatment of infantile rotavirus enteritis. Methods: 236 cases of infantile rotavirus enteritis diagnosed in our hospital were randomly divided into ribavirin group (A group), Yanhuning group (B group) and control group (C group) The onset time is divided into duration of 0-48 h group, duration of> 48 h group. Group C was given only rehydration, to maintain the basic balance of water and electrolyte balance; A group plus ribavirin (10-15) ng / (kg · d) intravenous drip, B group with Yan Hu Ning (5-8) mg / (kg · d) intravenous drip, the duration of fever, antipyretic time, diarrhea and the duration of the disease in each group were compared. Results: During the course of 0-48 h, the antipyretic time of group A and group B were significantly shorter than group C, and the total duration of group B was shorter than that of group C (all P <0.05). During the course of> 48 h, There was no significant difference in the antipyretic time between group A, group B and group C, and the total duration of disease in group B was shorter than that of group A and group C. CONCLUSIONS: Ribavirin is used during 0-48 h of onset and yanhuning is helpful for fever in patients with rotavirus enteritis. The use of midazolam can shorten the course of the disease and help to improve the symptoms of diarrhea.