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目的探讨血清同型半胱氨酸(HCY)水平与颈动脉粥样硬化的相关性。方法选取住院患者90例,采用彩色多普勒超声仪检测颈动脉,根据检测结果分为3组:内膜正常组、内膜增厚组和斑块形成组。用比浊法测定血清HCY浓度,并比较3组之间的差异。结果随着颈动脉粥样硬化程度的加重,血清HCY的浓度也明显地增高,差异有统计学意义(P<0.05)。血清HCY浓度与颈动脉粥样硬化的程度呈正相关。结论HCY在颈动脉粥样硬化的发生、发展中起重要的作用,血清HCY水平是动脉粥样硬化的一个独立危险因素。
Objective To investigate the relationship between serum homocysteine (HCY) level and carotid atherosclerosis. Methods 90 hospitalized patients were selected. The carotid arteries were detected by color Doppler sonography. The carotid arteries were divided into 3 groups according to the test results: normal intima, thickening intima and plaque formation. Serum HCY concentrations were measured by turbidimetry and the differences between the three groups were compared. Results With the aggravation of carotid atherosclerosis, serum HCY concentration also significantly increased, the difference was statistically significant (P <0.05). Serum HCY concentration and carotid atherosclerosis were positively correlated. Conclusion HCY plays an important role in the occurrence and development of carotid atherosclerosis. Serum HCY level is an independent risk factor of atherosclerosis.