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目的研究鼠曲草Gnaphlium affine全草化学成分。方法运用多种色谱技术分离鼠曲草全草中黄酮苷类成分,采用波谱技术和理化性质确定化合物的结构。结果从鼠曲草全草70%乙醇提取物中分离得到15个化合物,分别鉴定为3-methoxyphenol1-O-α-L-rhamnopyranosyl-(1→6)-O-β-D-glucopyranoside(1)、3′,5-dihydroxy-2-(4-hydroxybenzyl)-3-methoxybibenzyl(2)、大黄素甲醚(3)、松柏醛(4)、木犀草素-4′-O-β-D-葡萄糖苷(5)、款冬二醇3-O-棕榈酸酯(6)、白桦脂酸(7)、伞形香青酰胺(8)、对羟基桂皮酸甲酯葡萄糖苷(9)、valene-1(10)-ene-8,11-diol(10)、longumoside A(11)、大海米菊酰胺K(12)、槲皮素-3-O-芸香糖基-7-O-葡萄糖苷(13)、木犀草素-7-O-β-D-葡萄糖基-(1→6)-[(6′′′-O-咖啡酸)-β-D-葡萄糖苷](14)、毛蕊花苷(15)。结论化合物1、11为首次从该属植物中得到,化学物2、3、6、8、13、14为首次从该植物中分离得到。
Objective To study the chemical constituents of Gnaphlium affine. Methods A variety of chromatographic techniques were used to separate flavonoid glycosides from the whole plant grass. The structures of the compounds were determined by spectroscopic techniques and physicochemical properties. Results Fifteen compounds were isolated from the 70% ethanol extract of the whole plant of Schistosoma japonicum and identified as 3-methoxyphenol1-O-α-L-rhamnopyranosyl- (1 → 6) -O-β-D-glucopyranoside (1) , 3 ’, 5-dihydroxy-2- (4-hydroxybenzyl) -3-methoxybibenzyl (2), physcion (3), coniferyl aldehyde (4) Glycoside (5), beeswax 3-O-palmitate (6), betulinic acid (7), umbelliferone (8), methylparaben glucuronide (9), valene- 1 (10) -ene-8,11-diol (10), longumoside A (11), amikacin K (12), quercetin -3-0- rutosaccharide 7-O-glucoside 13), luteolin -7-O-β-D-glucosyl- (1 → 6) - [(6’’-O- caffeic acid) -β-D-glucoside] (15). Conclusions Compounds 1 and 11 were obtained from this genus for the first time and chemicals 2, 3, 6, 8, 13 and 14 were isolated from this genus for the first time.