微核试验作为染色体损伤及细胞有丝分裂受干扰的快速检测方法已被广泛地用于遗传毒理学,肿瘤细胞遗传学研究中,我们在抗精神病药物遗传毒理学系研究中,采用了该指标以考察抗精神病药物对培养细胞染色体的致畸效应。现将其中五氟利多的实验结果报告如下。一、方法:五氟利多的来源、工作液的配制已报道。受试者为无遗传性疾病、肿瘤、射线及致畸药物接触史的正常男性2例。年龄为15和21岁。实验分两组进行。在第一组中,每份血标本在培养24小时后分 Micronucleus test as a rapid detection method of chromosome damage and cell mitosis interference has been widely used in genotoxicity and tumor cytogenetics. We used this index in the study of genotoxicity of antipsychotics Teratogenic effects of antipsychotics on chromosomes of cultured cells. Herein, the experimental results of pentafluoridone are reported as follows. First, the method: the source of pentafluoride, working fluid preparation has been reported. The subjects were non-genetic disease, cancer, radiation and teratogenic drug exposure history of 2 normal men. Aged 15 and 21 years old. The experiment was divided into two groups. In the first group, each blood specimen was divided after 24 hours of culture