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胃肠激素广泛分布于胃肠道粘膜和神经丛.有报告Crohn氏病手术切除的肠段标本和直肠粘膜活检标本中含血管活性肠肽(vasoactive intestinal peptide,VIP)的神经纤维增多增粗,VIP含量增加;但也有持不同意见的报告。本文作者对64份Crohn氏病、溃疡生结肠炎、非特异性结肠炎及大致正常的直肠粘膜活检标本进行VIP、神经降压素(neurotensin,NT)和生长抑素(somatostatin,SRIF)的含量测定,以探讨其在炎症性肠病中的病理生理意义。
Gut hormones are widely distributed in the gastrointestinal mucosa and plexus.It has been reported that Crohn’s disease surgically resected bowel specimens and rectal mucosal biopsies containing vasoactive intestinal peptide (vasoactive intestinal peptide, VIP) increased nerve fiber thickening, VIP content increased; but there are also dissenting reports. The authors tested the levels of VIP, neurotensin (NT) and somatostatin (SRIF) in 64 Crohn’s disease, ulcerative colitis, nonspecific colitis and approximately normal rectal mucosal biopsy specimens To explore its pathophysiological significance in inflammatory bowel disease.