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目的:观察益气祛瘀汤联合西药治疗高原性红细胞增多症的临床疗效。方法:将90例高原性红细胞增多症患者随机分为对照组和治疗组,其中对照组予低分子右旋糖酐和卡托普利治疗,治疗组予益气祛瘀汤联合低分子右旋糖酐和卡托普利治疗,两组疗程均为4周,每周均放血100mL。结果:治疗组头痛、乏力、紫绀及结膜充血症,治疗组与对照组明显改善,总有效率高于对照组。(P<0.05,P<0.01)。两组患者RBC、Hb、Hct治疗前后水平比较:两组治疗后各项水平均较前明显下降,但治疗组明显优于对照组(P<0.05,P<0.01)。血液流变学相关指标比较:全血黏度切变率1(1/s)、全血低切还原黏度、血浆黏度值、红细胞聚集指数、纤维蛋白原水平两组较治疗前都下降,但治疗组明显优于对照组(P<0.05,P<0.01)。结论:益气化瘀汤联合西药可有效改善临床症状,降低红细胞计数、血红蛋白,改善血液流变学,是治疗高原性红细胞增多症较满意的药物。
Objective: To observe the clinical efficacy of Yiqi Quyu Decoction combined with western medicine in the treatment of high altitude polycythemia. Methods: 90 cases of patients with high altitude polycythemia were randomly divided into control group and treatment group, in which the control group was treated with low molecular dextran and captopril, the treatment group was treated with Yiqi Quyu Decoction combined with low molecular weight dextran and captopril Lee treatment, the two groups were 4 weeks course of treatment, each week bleeding 100mL. Results: The headache, fatigue, cyanosis and conjunctival hyperemia in the treatment group were significantly improved in the treatment group and the control group, and the total effective rate was higher than that in the control group. (P <0.05, P <0.01). The levels of RBC, Hb and Hct in the two groups before and after treatment were significantly lower than those in the control group (P <0.05, P <0.01). Blood rheology-related indicators of comparison: the whole blood viscosity shear rate 1 (1 / s), low blood viscosity reduction, plasma viscosity, erythrocyte aggregation index, fibrinogen levels were lower than before treatment, but the treatment Group was significantly better than the control group (P <0.05, P <0.01). Conclusion: Yiqi Huayu decoction combined with western medicine can effectively improve clinical symptoms, reduce red blood cell count and hemoglobin, improve hemorheology, and is a satisfactory drug for the treatment of high altitude erythrocytosis.