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目的:研究血管内皮生长因子(VEGF)在大肠癌、大肠腺瘤和癌旁正常大肠黏膜标本中的表达,并探讨其表达与大肠癌发生、发展及转移的关系。方法:通过免疫组化SP法检测89例大肠癌、22例大肠腺瘤、26例癌旁正常大肠黏膜标本中VEGF表达及与大肠癌临床病理特征的关系。结果:VEGF在大肠癌组织中的阳性率(71.9%,64/89)明显高于其在癌旁正常大肠黏膜组织(30.8%,8/26)、大肠腺瘤组织(40.9%,9/22)中的阳性率,差异有统计学意义(P<0.01);VEGF在大肠癌组织中的表达水平与肿瘤Dukes分期、有无淋巴结转移及患者年龄有关(P<0.05),与肿瘤组织学分级和患者性别无关。结论:VEGF表达升高与大肠癌的发生、发展、浸润及淋巴结转移有关,检测VEGF的表达情况有助于判断大肠癌的恶性程度及肿瘤预后。
Objective: To investigate the expression of vascular endothelial growth factor (VEGF) in colorectal cancer, colorectal adenoma and normal colorectal mucosa specimens and to investigate its relationship with the occurrence, development and metastasis of colorectal cancer. Methods: The expression of VEGF in 89 cases of colorectal cancer, 22 cases of colorectal adenoma and 26 cases of normal colorectal mucosa adjacent to carcinoma was detected by immunohistochemical SP method and its correlation with the clinicopathological features of colorectal cancer. Results: The positive rate of VEGF in colorectal cancer was significantly higher than that in normal colorectal mucosa (30.8%, 8/26), colorectal adenoma (40.9%, 9/22 ), The difference was statistically significant (P <0.01). The expression of VEGF in colorectal carcinoma was correlated with Dukes stage, lymph node metastasis and patient’s age (P <0.05), but not with tumor histological grade Has nothing to do with the patient’s gender. Conclusion: The increased expression of VEGF is associated with the occurrence, development, invasion and lymph node metastasis of colorectal cancer. Detecting the expression of VEGF is helpful to evaluate the malignant degree and tumor prognosis of colorectal cancer.