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动态测定76例临床明确诊断的急性心肌梗塞患者和15例正常对照组肿瘤坏死因子和血浆神经肽Y的水平。结果显示,正常对照组NPY为93.3±10.6ng/L,急性心肌梗塞组在发病后1天NPY异常升高,为160.2±26.3ng/L,发病后第7天为121.3±24.7ng/L,均高于正常对照组(p<0.05);与NPY不同,正常对照组的TNF为0.97±0.38μg/L,在急性心肌梗塞发病后第1天升高至2.48±0.89μg/L(p<0.01),但发病后第3天降至1.12±0.37μg/L,已接近正常(p>0.05)。提示,TNF在急性心肌梗塞的发生中有重要作用,但与患者预后无直接关系;而血浆神经肽Y的水平不仅与急性心肌梗塞患者的发生有关,而且在急性心肌梗塞的病程和预后中有重要价值。
The levels of tumor necrosis factor and plasma neuropeptide Y in 76 clinically diagnosed acute myocardial infarction patients and 15 normal controls were determined dynamically. The results showed that the NPY of the normal control group was 93.3 ± 10.6ng / L, the abnormal NPY of the acute myocardial infarction group was 160.2 ± 26.3ng / L on the 1st day after onset, and 121.3 ± 24.7ng / L on the 7th day after onset, (P <0.05). Compared with NPY, the TNF of normal control group was 0.97 ± 0.38μg / L, increased to 2.48 ± 0.89μg / L on the first day after acute myocardial infarction (p < 0.01), but it dropped to 1.12 ± 0.37μg / L on the third day after onset, which was close to normal (p> 0.05). It is suggested that TNF plays an important role in the occurrence of acute myocardial infarction but has no direct relationship with the prognosis of patients. However, the level of plasma neuropeptide Y is not only related to the occurrence of acute myocardial infarction, but also in the course and prognosis of acute myocardial infarction Important value.