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应用DNA含量图像分析技术,对21例经44次手术切除的复发性肝细胞癌的DNA含量进行了对比测定。结果显示,8例(38.1%)复发肝癌的DNA含量与其原发肝癌明显不同,提示前者为不同克隆来源的新生肝癌;13例(61.9%)复发肝癌的DNA含量与其原发肝癌甚为相似,提示两者来自相同的肿瘤克隆;这两组的手术平均间隔期分别为25±9.9月和7.9±3.1月,术后平均生存期分别为51±20.8月和27.7±14.2月。研究表明,复发性肝癌中的多数来自其原发肝癌的残留,但部分复发性肝癌确系再发的原发性肝癌。本文认为,肝癌的组织发生存在单中心与多中心两种途径,手术切除仍是复发性肝癌有效的治疗方法。
Using DNA content image analysis technique, the DNA content of 21 cases of recurrent hepatocellular carcinoma excised after 44 operations was compared. The results showed that the DNA content of 8 cases (38.1%) of recurrent hepatocellular carcinoma was significantly different from that of primary hepatocellular carcinoma, suggesting that the former was a new source of hepatocellular carcinoma from different clones; the DNA content of 13 cases (61.9%) of recurrent hepatocellular carcinoma was similar to that of primary hepatocellular carcinoma. It is suggested that the two are from the same tumor clone; the mean interval between the two groups was 25±9.9 months and 7.9±3.1 months respectively, and the average survival time was 51±20.8 months and 27.7±14.2 months, respectively. Studies have shown that the majority of recurrent hepatocellular carcinomas are from the residue of their primary liver cancer, but some recurrent hepatocarcinomas are indeed recurrent primary liver cancers. This article believes that there is a single-center and multi-center pathogenesis of liver cancer, and surgical resection is still an effective treatment for recurrent liver cancer.