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采用豚鼠离体心脏、兔胸主动脉条和麻醉大鼠急性降压等实验，初步观察了两种新的神经酰胺（代号分别为 Ｎ１和 Ｎ２）对心血管的药理作用。结果表明：Ｎ１和 Ｎ２（１００μｍｏｌ／Ｌ，２００μｍｏｌ／Ｌ），对豚鼠离体心脏收缩力和心率都具有明显的抑制作用。但Ｎ１和Ｎ２（２００μｍｏｌ／Ｌ）均不能阻断ＩＳＯ和ＮＡ增加豚鼠离体心脏收缩力和心率的作用。５０μｍｏｌ／Ｌ和１００μｍｏｌ／Ｌ的Ｎ１或Ｎ２对兔胸主动脉条无作用，对ＫＣＩ和Ａｄｒ诱发的主动脉条收缩也无影响。静注１．ｍｇ／ｋｇ和３．２ｍｇ／ｋｇ的Ｎ１或Ｎ２对麻醉大鼠具有急性降压作用，阿托品可阻断其降压作用。提示Ｎ１和Ｎ２的药理作用可能与Ｍ受体有关。
Using guinea pig isolated hearts, rabbit thoracic aorta strips, and anesthetized rats in acute hypotensive experiments, the pharmacological effects of two new ceramides (codenamed N1 and N2) on cardiovascular function were initially observed. The results showed that N1 and N2 (100 μmol/L, 200 μmol/L) had significant inhibitory effects on isolated heart contractility and heart rate in guinea pigs. However, neither N1 nor N2 (200 μmol/L) could block the effect of ISO and NA on contractile force and heart rate of isolated guinea pig hearts. 50μmol/L and 100μmol/L N1 or N2 had no effect on rabbit thoracic aortic strips, and had no effect on KCI and Adr-induced aortic strip contraction. Intrajectory 1. N1 or N2 at mg/kg and 3.2 mg/kg had acute antihypertensive effect on anesthetized rats, and atropine could block its antihypertensive effect. It suggests that the pharmacological effects of N1 and N2 may be related to M receptors.