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目的:采用天麻钩藤饮联合盐酸贝那普利(洛丁新)治疗肝阳偏亢型高血压,观察分析两者结合治疗的临床有效性和安全性。方法:收集2014年1月—2014年12月来我院门诊就诊的原发性高血压(肝阳偏亢型)患者181例。采用随机数字表法,将全部病例随机分成治疗组(n=90例)和对照组(n=91例)。对照组均给予盐酸贝那普利(洛丁新)10 mg口服1次/d;治疗组在对照组基础上给予天麻钩藤饮水煎剂,1剂/d,分早晚服用。4周为1个疗程。治疗1个疗程后比较两组治疗后血压、血脂水平变化和不良反应情况。结果:治疗1个疗程后比较结果发现,治疗组总有效率为84.44%,对照组为71.43%,两组总有效率比较差异有统计学意义(P<0.05);用药后两组血压均明显下降(P<0.05),治疗组血压降低程度明显高于对照组(P<0.05);治疗组24 h平均收缩压明显降低,血压晨峰现象明显好转,与对照组比较差异有统计学意义(P<0.05);治疗组治疗后TC、TG、HDLC、LDLC均优于对照组,以上差异具有统计学意义(P<0.05),治疗组不良反应和对照组发生人数基本持平,无统计学意义(P>0.05)。结论:天麻钩藤饮联合盐酸贝那普利(洛丁新)治疗肝阳偏亢型高血压降压临床效果满意,血压、血脂明显改善,对肾功能有一定的保护作用,临床安全性好,适合临床广泛应用。
Objective: To observe the clinical efficacy and safety of Tianma Gouteng Decoction combined with benazepril hydrochloride (LBP) in treating liver-yang hyperactivity hypertension. Methods: A total of 181 patients with primary hypertension (liver yang hyperactivity type) from January 2014 to December 2014 were enrolled in our hospital. All patients were randomly divided into treatment group (n = 90) and control group (n = 91) using random number table method. The control group were given benazepril hydrochloride (LOXIN) 10 mg orally once / d; the treatment group was given Tianma Gouteng decoction on the basis of the control group, 1 dose / d, points in the morning and evening. 4 weeks for a course of treatment. After a course of treatment, blood pressure, blood lipid level and adverse reactions were compared between the two groups after treatment. Results: After 1 course of treatment, the results showed that the total effective rate was 84.44% in the treatment group and 71.43% in the control group, the total effective rate was significantly different between the two groups (P <0.05) (P <0.05). The decrease of blood pressure in the treatment group was significantly higher than that in the control group (P <0.05). The mean systolic blood pressure in the treatment group decreased significantly at 24 h, the morning peak of blood pressure was significantly improved, and the difference was statistically significant P <0.05). The TC, TG, HDLC and LDLC of the treatment group were better than those of the control group after treatment, the above differences were statistically significant (P <0.05). The adverse reactions in the treatment group and the control group were basically the same (P> 0.05). CONCLUSION: Tianma Gouteng Decoction combined with benazepril hydrochloride (Ludingxin) has satisfactory clinical effect in lowering blood pressure and blood lipid, and has a certain protective effect on renal function with good clinical safety , Suitable for clinical application.