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目的考查依据《抗菌药物临床应用指导原则》[1]加强管理后骨科围手术期抗菌药物应用情况。方法对2005年3月81例骨科Ⅰ、Ⅱ类切口手术患者和2006年3月84例骨科Ⅰ、Ⅱ类切口手术患者抗菌药物使用情况进行比较调查。结果2005年组、2006年组围手术期预防性应用抗菌药物使用率分别为100%、89.29%(P<0.05),2006年组手术前期、手术后期抗菌药物使用率下降(P<0.05),手术期使用率提高(P<0.05),术后预防用药时间缩短(P<0.05)。2006年组应用二联、三联抗菌药物者比2005年组减少。结论依据《抗菌药物临床应用指导原则》加强骨科围手术期抗菌药物应用管理行之有效,但仍有不足之处需进一步加强管理。
Objective To examine the basis of “guidelines for clinical use of antimicrobial agents” [1] to strengthen the management of orthopedic perioperative antibacterial drugs. Methods A total of 81 cases of orthopedics in March 2005 in patients with type Ⅰ and Ⅱ incision surgery and March 2006 84 cases of orthopedics Ⅰ, Ⅱ incision surgery patients were compared antibacterial use. Results The use rates of prophylactic antibiotics in perioperative period were 100% and 89.29% respectively in the group of 2005 and 2006 (P <0.05). The usage of antibacterials in the group of preoperative and postoperative decreased in 2006 (P <0.05) The operative rate increased (P <0.05) and the prophylactic medication time shortened (P <0.05). In 2006, two groups were used, and the number of triple antimicrobial agents was less than that in 2005. Conclusion Based on the Guiding Principles of Clinical Application of Antibacterials, it is effective to strengthen the administration of antimicrobial agents in perioperative period of orthopedics. However, there are still some shortcomings to further strengthen the management.